Seafood with Creamy Creole Sauce: Southern Comfort in a Single Skillet

If you’re a fan of bold flavors and rich comfort food, this Seafood with Creamy Creole Sauce is a dish you won’t want to miss.

Combining tender shrimp, scallops, or fish with a luscious, spiced cream sauce, this recipe brings the warmth and soul of Southern Creole cooking right to your table in under 30 minutes.

The dish starts with your choice of seafood—shrimp, scallops, or fillets of salmon, catfish, or tilapia. After patting them dry, the seafood is seasoned with a flavorful mix of salt,

black pepper, Creole seasoning, smoked paprika, and garlic powder. It’s then seared in a blend of olive oil and butter until golden and perfectly cooked.

In the same skillet, a base for the creamy Creole sauce is built by sautéing finely chopped onions, bell peppers, and garlic in butter.

Layers of flavor are added through Creole seasoning, smoked paprika, cayenne pepper, and Old Bay (if desired), bringing both depth and a touch of heat.

A splash of seafood stock or chicken broth helps deglaze the pan, allowing all those delicious browned bits to meld into the sauce.

The richness comes next: heavy cream, tomato paste, Dijon mustard, Worcestershire sauce, and a dash of hot sauce are stirred in, simmering together until thickened.

For extra decadence, grated Parmesan cheese can be added and melted into the sauce.

Finally, a squeeze of fresh lemon juice brightens the dish and balances the creamy texture.

Once the seafood is returned to the pan, it’s gently simmered in the sauce to absorb all the robust flavors.    A sprinkle of fresh chopped parsley adds a pop of color and freshness to finish the dish.

Serving suggestions are plentiful: this dish shines over a bed of Cajun rice, creamy grits, mashed potatoes, or even pasta. Crusty bread is highly recommended to soak up every drop of the sauce.

For a full, well-rounded meal, consider pairing it with sautéed greens or grilled vegetables.

Leftovers can be stored in an airtight container for up to two days in the refrigerator and gently reheated with a splash of cream or broth to bring the sauce back to life.

With only 10 minutes of prep and 15 minutes of cooking, this restaurant-quality dish is perfect for weeknights, dinner parties,

or special occasions. It’s a Southern classic reimagined with creamy elegance—satisfying, soulful, and unforgettable.